Ultrasensitive detection of TCR hypervariable region in solid - tissue RNA - seq data
نویسندگان
چکیده
70 words) Characterization of tissue-infiltrating T cell repertoire is critical to understanding tumorimmune interactions and autoimmune disease etiology. We present TRUST, an open source algorithm for calling the TCR transcript hypervariable CDR3 regions using unselected RNAseq data profiled from solid tissues. TRUST achieved high sensitivity in CDR3 calling even for samples with low sequencing depth and has demonstrated utilities in its application to large tumor cohorts. peer-reviewed) is the author/funder. All rights reserved. No reuse allowed without permission. The copyright holder for this preprint (which was not . http://dx.doi.org/10.1101/073395 doi: bioRxiv preprint first posted online Sep. 5, 2016;
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